12 Days Till Inauguration, a Very Dangerous Time, Lacking Statutory Authority

Leadership in this interval  leading up to inauguration is an informal collective of very competent people, who unfortunately lack the statutory authority on which all notions of deterrence rest.

The situation persists because  the risk of domestic unrest is more real to the politically astute than the risk of hostile foreign powers.

A hostile foreign power might be emboldened to shortly take a risk we would normally call a miscalculation.  Their numbers might actually add up.

The remedy to risk from hostile foreign powers is to reestablish the statutory authority that is the basis all forms deterrence, as provided for by the Constitution.

It’s much cheaper than fighting a war.

 

 

(CNN) Top White House national security officials are considering resigning; Please Don’t

(CNN) Top White House national security officials are considering resigning.  Quoting,

Several of President Trump’s top aides, including national security adviser Robert O’Brien, are considering resigning in the wake of his response to a pro-Trump mob breaching the US Capitol today.

This is addressed to those officials. Please don’t resign. We need you more than ever.

This is a day which will live in infamy, but not yours. The  minor shame of serving to the end is erased by the service you have rendered. The numbers of experienced professionals like yourselves, who stepped up for the most difficult jobs of their lives, is the most impressive fact of this administration.  You have together borne the shield of decency and preserved the Constitution.

On 12/21, I began to wonder: Coup in the United States? In May of 1964, this almost happenedIt may yet emerge as more real than mere ambition, prevented by one insuperable obstacle, YOU.

You, as interlocutors with the rest of  government, were the barrier to illegalities of usurpation. You defended the Constitution and preserved the Republic.  This remains your obligation  and reward until Inauguration Day, unless the 25th Amendment is invoked.

Even if history does not shower you with the praise of the victorious, if you stay the course of the Republic, this will be your finest hour.

Half Doses of Moderna, Pfizer Vaccines, a Good Idea; Mexican Encephalitis

So there’s no misunderstanding, I would drive three hours to get either shot. But there is a strong argument for a half dose.

(Reuters) Mexican doctor hospitalized after receiving COVID-19 vaccine is concerning. Quoting,

“The initial diagnosis is encephalomyelitis,” the Health Ministry said in a statement released on Friday night. Encephalomyelitis is an inflammation of the brain and spinal cord.

Encephalomyelitis does not result from atopy. It is a result of a cell-mediated autoimmune reaction. In the few 3rd World countries that still use the Semple rabies vaccine, it is a regular and frequently lethal side effect. Brain damage is frequent in survivors.

The Semple vaccine is made of animal nerve tissue with no purification. When encephalomyelitis results from this vaccine, it is the result of introducing into the body proteins which are both similar and different. The foreignness of the protein induces an immune response that also attacks native proteins. But this mechanism gives no hint as to why it would occur with an RNA vaccine.

A clue is offered by (Nature, 12/20/2020) The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice. For a neat summary, see (ScienceDaily) COVID-19 virus enters the brain, research strongly suggests.

The Mexican physician has a history of severe allergic reactions. How could this tie in with encephalomyelitis? A possible mechanism:

  • The patient had a “standard” anaphylactic reaction, which involves a huge histamine release.
  • The Pfizer and Moderna vaccines cause cells at the injection site to produce a flood of spike protein, which, unbound to an adjuvant, is highly mobile.
  • Since it is now known that the brain contains mast cells, the blood-brain barrier suddenly became porous. Even with prompt treatment, a substantial quantity of spike protein passed the barrier.
  • With no previous exposure to spike protein, the nature of the immune response within the brain is a mystery. Encephalomyelitis could be the visible result of a massively apoptotic event.
  • Had the patient  received epinephrine prophylaxis with the vaccine, this might have been avoided. Something to consider?

In traditional vaccines, adjuvants have been combined with antigen to increase the potency of the shot. Various theories explain why adjuvants work:

  • The immune system requires insult to react. As a minor irritant, an adjuvant causes the immune system to respond more strongly to the antigen.
  • When an antigen is attached to a poorly soluble adjuvant, such as alum, the half life of the antigen in circulation is greatly increased. This also reduces the mobility of the antigen.

As potentially toxic substances, adjuvants went out of fashion for a while, with preference for highly potent antigens synthesized by recombinant techniques. Now adjuvants are back in favor in new flavors.

RNA vaccines produce a sudden flood of unbound s-protein antigen. More traditional vaccines present antigens bound to larger structures, either adjuvants, or virus-like-particles. This reduces the mobility of the antigen, in this case s-protein, lessening the chance it can pass the blood-brain barrier. This “safety feature” cannot be incorporated into RNA vaccines.

Since this is unlikely to have a large lay readership, we could finish with Paracelsus. You know what he said. Even a handful of cases of encephalomyelitis could frustrate mass immunization.

So cut the dose in half. Yes, I’m still driving three hours for the shot. I’ll take mine with a side of epinephrine.

 

 

 

 

 

 

Now is the Winter of Our Discontent; a Painting for Today

(click to enlarge)

I’m too much of a realist to revel in a single day, and wish you a happy new year. From (Shakespeare) Richard III,

Now is the winter of our discontent
Made glorious summer by this sun of York;
And all the clouds that lour’d upon our house
In the deep bosom of the ocean buried.
Now are our brows bound with victorious wreaths;
Our bruised arms hung up for monuments;
Our stern alarums changed to merry meetings,
Our dreadful marches to delightful measures.
I am determined to prove a villain
And hate the idle pleasures of these days.
Plots have I laid, inductions dangerous,
By drunken prophecies, libels and dreams,
To set my brother Clarence and the king
In deadly hate the one against the other:

The oil-on-canvas painting is inspired by a  shack in southern New Mexico, where I saw orange desert lighting, bolts spanning the entire sky.  It was made in an unusual way.  Mars Black mixed with heavy medium was applied in heavy impasto. The line drawing was inscribed with a stick. It was set aside to dry for a month.  All of the colors and shades are the result of thin glazes. Lit straight on, the canvas appears inscrutably dark. The photo was taken with side lighting.

Look!  In the window of the shack! Is that glow the lamp of a solitary dweller, a beacon of hope, or just the reflection of lightning?

Your choice, the freedom of imagination.